Members: Benjamin Tay Zikai, David Gonzalez-Rodriguez, Marcos
Metastasis which contributes to almost 90% of cancer related deaths, is one of the most studied diseases due to its pervasiveness. To improve cancer treatment, biological effects of cancer along with the physical effects of flow within the tumor microenvironment must be elucidated. Interstitial flow has been shown to influence cancer cell migration. However, the relationship between interstitial flow and cell density in a tumor in affecting cancer cell migration is not well understood. Theoretical models and experimental observations in simplified in-vitro systems would help us understand the biophysical outcomes of the relationships between various biological entities. This study could help us understand the biophysical aspects of cancer and may aid others on the combined effort in improving cancer treatment.